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Design

Biostatistics & Study Analytics

Sample size, power, interim and adaptive design — all in one workbench.

Ask AI Forecast
Sample sizes calculated
318
Power analyses (30d)
84
Interim analyses due
6
Adaptive amendments
4

Sample Size Calculator

Save to Protocol
N per arm
242
Total N
484
Achieved power
0.80
Detectable effect
0.50

Power Analysis Dashboard

TrialEndpointNPowerTrendStatus
ONCO-204PFS (HR)412/4800.78
At Risk
ONCO-307ORR (binary)240/2400.86
Adequate
CARD-118MACE (TTE)1640/18000.81
Adequate
RD-118FEV1 change88/1400.62
Underpowered

Interim Analysis Planner

Generate DSMB Package
ONCO-204
Interim 1
α-spending: O'Brien-Fleming
Info fraction
50%
Conditional power
0.71
Continue
ONCO-307
Interim 1
α-spending: Pocock
Info fraction
67%
Conditional power
0.88
Stop for efficacy
RD-118
Futility 1
α-spending: O'Brien-Fleming
Info fraction
40%
Conditional power
0.18
Stop for futility

Adaptive Design Monitor

Model new adaptation
TrialAdaptation typeTriggerStatusApproval
ONCO-204Sample size re-estimationConditional power < 0.80
Triggered
IRB pending
CARD-118Response-adaptive randomisationArm imbalance > 15%
Active
Approved
RD-204Seamless phase 2/3Pre-planned at IA-1
Scheduled
Approved